12 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 3, 2021 | 7:00 PM | Fri | Duke | @ | Charlotte | CUSA | L | 28 | 31 | 0 | 1 | L 1 | |
| 2 | Sep 10, 2021 | 8:00 PM | Fri | Duke | North Carolina A&T | Non-Major | W | 45 | 17 | 1 | 1 | W 1 | ||
| 3 | Sep 18, 2021 | 4:00 PM | Sat | Duke | Northwestern | Big Ten | W | 30 | 23 | 2 | 1 | W 2 | ||
| 4 | Sep 25, 2021 | 4:00 PM | Sat | Duke | Kansas | Big 12 | W | 52 | 33 | 3 | 1 | W 3 | ||
| 5 | Oct 2, 2021 | 12:00 PM | Sat | Duke | @ | North Carolina | ACC | L | 7 | 38 | 3 | 2 | L 1 | |
| 6 | Oct 9, 2021 | 12:30 PM | Sat | Duke | Georgia Tech | ACC | L | 27 | 31 | 3 | 3 | L 2 | ||
| 7 | Oct 16, 2021 | 12:30 PM | Sat | Duke | @ | Virginia | ACC | L | 0 | 48 | 3 | 4 | L 3 | |
| 8 | Oct 30, 2021 | 4:00 PM | Sat | Duke | @ | (13) Wake Forest | ACC | L | 7 | 45 | 3 | 5 | L 4 | |
| 9 | Nov 6, 2021 | 12:00 PM | Sat | Duke | Pitt | ACC | L | 29 | 54 | 3 | 6 | L 5 | ||
| 10 | Nov 13, 2021 | 3:30 PM | Sat | Duke | @ | Virginia Tech | ACC | L | 17 | 48 | 3 | 7 | L 6 | |
| 11 | Nov 18, 2021 | 7:30 PM | Thu | Duke | Louisville | ACC | L | 22 | 62 | 3 | 8 | L 7 | ||
| 12 | Nov 27, 2021 | 12:30 PM | Sat | Duke | Miami (FL) | ACC | L | 10 | 47 | 3 | 9 | L 8 |
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