13 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 2, 2022 | 7:30 PM | Fri | Duke | Temple | American | W | 30 | 0 | 1 | 0 | W 1 | ||
| 2 | Sep 10, 2022 | 12:00 PM | Sat | Duke | @ | Northwestern | Big Ten | W | 31 | 23 | 2 | 0 | W 2 | |
| 3 | Sep 17, 2022 | 6:00 PM | Sat | Duke | North Carolina A&T | Non-Major | W | 49 | 20 | 3 | 0 | W 3 | ||
| 4 | Sep 24, 2022 | 12:00 PM | Sat | Duke | @ | Kansas | Big 12 | L | 27 | 35 | 3 | 1 | L 1 | |
| 5 | Oct 1, 2022 | 7:30 PM | Sat | Duke | Virginia | ACC | W | 38 | 17 | 4 | 1 | W 1 | ||
| 6 | Oct 8, 2022 | 4:00 PM | Sat | Duke | @ | Georgia Tech | ACC | L | 20 | 23 | 4 | 2 | L 1 | |
| 7 | Oct 15, 2022 | 8:00 PM | Sat | Duke | North Carolina | ACC | L | 35 | 38 | 4 | 3 | L 2 | ||
| 8 | Oct 22, 2022 | 12:30 PM | Sat | Duke | @ | Miami (FL) | ACC | W | 45 | 21 | 5 | 3 | W 1 | |
| 9 | Nov 4, 2022 | 7:00 PM | Fri | Duke | @ | Boston College | ACC | W | 38 | 31 | 6 | 3 | W 2 | |
| 10 | Nov 12, 2022 | 12:00 PM | Sat | Duke | Virginia Tech | ACC | W | 24 | 7 | 7 | 3 | W 3 | ||
| 11 | Nov 19, 2022 | 12:00 PM | Sat | Duke | @ | Pitt | ACC | L | 26 | 28 | 7 | 4 | L 1 | |
| 12 | Nov 26, 2022 | 3:30 PM | Sat | Duke | Wake Forest | ACC | W | 34 | 31 | 8 | 4 | W 1 | ||
| 13 | Dec 28, 2022 | 2:00 PM | Wed | Duke | N | UCF | American | W | 30 | 13 | 9 | 4 | W 2 | Military Bowl |
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