| 1 | 10:10 | LOU | Trevion Cooley 48 yard pass from Malik Cunningham (James Turner kick) | 7 | 0 |
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| 5:33 | DUKE | Charlie Ham 22 yard field goal | 7 | 3 |
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| 0:58 | LOU | Marshon Ford 20 yard pass from Malik Cunningham (James Turner kick) | 14 | 3 |
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| 2 | 11:26 | LOU | Malik Cunningham 44 yard run (James Turner kick) | 21 | 3 |
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| 8:34 | DUKE | Charlie Ham 28 yard field goal | 21 | 6 |
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| 7:29 | LOU | Malik Cunningham 72 yard run (James Turner kick) | 28 | 6 |
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| 1:36 | LOU | Jalen Mitchell 11 yard run (James Turner kick) | 35 | 6 |
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| 0:00 | DUKE | Charlie Ham 26 yard field goal | 35 | 9 |
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| 3 | 7:46 | LOU | Jordan Watkins 19 yard pass from Malik Cunningham (James Turner kick) | 42 | 9 |
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| 5:06 | DUKE | Jalon Calhoun 6 yard run (Charlie Ham kick) | 42 | 16 |
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| 3:15 | LOU | Ahmari Huggins-Bruce 12 yard pass from Malik Cunningham (kick failed) | 48 | 16 |
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| 4 | 14:54 | DUKE | Riley Leonard 35 yard run (2-point pass failed) | 48 | 22 |
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| 12:17 | LOU | Tyler Harrell 36 yard pass from Malik Cunningham (James Turner kick) | 55 | 22 |
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| 5:10 | LOU | Aidan Robbins 34 yard run (Brock Travelstead kick) | 62 | 22 |
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Team Stats