11 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | T | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 13, 1980 | Sat | Michigan State | @ | Illinois | Big Ten | L | 17 | 20 | 0 | 1 | 0 | L 1 | |
| 2 | Sep 20, 1980 | Sat | Michigan State | @ | Oregon | Pac-10 | L | 7 | 35 | 0 | 2 | 0 | L 2 | |
| 3 | Sep 27, 1980 | Sat | Michigan State | Western Michigan | MAC | W | 33 | 7 | 1 | 2 | 0 | W 1 | ||
| 4 | Oct 4, 1980 | Sat | Michigan State | (7) Notre Dame | Ind | L | 21 | 26 | 1 | 3 | 0 | L 1 | ||
| 5 | Oct 11, 1980 | Sat | Michigan State | @ | Michigan | Big Ten | L | 23 | 27 | 1 | 4 | 0 | L 2 | |
| 6 | Oct 18, 1980 | Sat | Michigan State | Wisconsin | Big Ten | L | 7 | 17 | 1 | 5 | 0 | L 3 | ||
| 7 | Oct 25, 1980 | Sat | Michigan State | @ | Purdue | Big Ten | L | 25 | 36 | 1 | 6 | 0 | L 4 | |
| 8 | Nov 1, 1980 | Sat | Michigan State | (9) Ohio State | Big Ten | L | 16 | 48 | 1 | 7 | 0 | L 5 | ||
| 9 | Nov 8, 1980 | Sat | Michigan State | Northwestern | Big Ten | W | 42 | 10 | 2 | 7 | 0 | W 1 | ||
| 10 | Nov 15, 1980 | Sat | Michigan State | @ | Minnesota | Big Ten | W | 30 | 12 | 3 | 7 | 0 | W 2 | |
| 11 | Nov 22, 1980 | Sat | Michigan State | Iowa | Big Ten | L | 0 | 41 | 3 | 8 | 0 | L 1 |
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