| 1 | Aug 31, 2019 | 7:30 PM | Sat | Wyoming | | Missouri | SEC | W | 37 | 31 | 1 | 0 | W 1 | Jonah Field War Memorial Stadium - Laramie, Wyoming |
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| 2 | Sep 7, 2019 | 7:00 PM | Sat | Wyoming | @ | Texas State | Sun Belt | W | 23 | 14 | 2 | 0 | W 2 | Bobcat Stadium - San Marcos, Texas |
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| 3 | Sep 14, 2019 | 5:00 PM | Sat | Wyoming | | Idaho | Non-Major | W | 21 | 16 | 3 | 0 | W 3 | Jonah Field War Memorial Stadium - Laramie, Wyoming |
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| 4 | Sep 21, 2019 | 3:30 PM | Sat | Wyoming | @ | Tulsa | American | L | 21 | 24 | 3 | 1 | L 1 | Skelly Field at H.A. Chapman Stadium - Tulsa, Oklahoma |
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| 5 | Sep 28, 2019 | 8:00 PM | Sat | Wyoming | | Nevada-Las Vegas | MWC | W | 53 | 17 | 4 | 1 | W 1 | Jonah Field War Memorial Stadium - Laramie, Wyoming |
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| 6 | Oct 12, 2019 | 10:30 PM | Sat | Wyoming | @ | San Diego State | MWC | L | 22 | 26 | 4 | 2 | L 1 | SDCCU Stadium - San Diego, California |
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| 7 | Oct 19, 2019 | 4:00 PM | Sat | Wyoming | | New Mexico | MWC | W | 23 | 10 | 5 | 2 | W 1 | Jonah Field War Memorial Stadium - Laramie, Wyoming |
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| 8 | Oct 26, 2019 | 2:00 PM | Sat | Wyoming | | Nevada | MWC | W | 31 | 3 | 6 | 2 | W 2 | Jonah Field War Memorial Stadium - Laramie, Wyoming |
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| 9 | Nov 9, 2019 | 10:15 PM | Sat | Wyoming | @ | (21) Boise State | MWC | L | 17 | 20 | 6 | 3 | L 1 | Albertsons Stadium - Boise, Idaho |
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| 10 | Nov 16, 2019 | 4:00 PM | Sat | Wyoming | @ | Utah State | MWC | L | 21 | 26 | 6 | 4 | L 2 | Merlin Olsen Field at Maverik Stadium - Logan, Utah |
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| 11 | Nov 22, 2019 | 9:30 PM | Fri | Wyoming | | Colorado State | MWC | W | 17 | 7 | 7 | 4 | W 1 | Jonah Field War Memorial Stadium - Laramie, Wyoming |
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| 12 | Nov 30, 2019 | 2:00 PM | Sat | Wyoming | @ | Air Force | MWC | L | 6 | 20 | 7 | 5 | L 1 | Falcon Stadium - Colorado Springs, Colorado |
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| 13 | Dec 31, 2019 | 4:30 PM | Tue | Wyoming | N | Georgia State | Sun Belt | W | 38 | 17 | 8 | 5 | W 1 | Arizona Bowl (Arizona Stadium - Tucson, Arizona) |
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