13 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 3, 2010 | Fri | Toledo | Arizona | Pac-10 | L | 2 | 41 | 0 | 1 | L 1 | ||
| 2 | Sep 11, 2010 | Sat | Toledo | @ | Ohio | MAC | W | 20 | 13 | 1 | 1 | W 1 | |
| 3 | Sep 18, 2010 | Sat | Toledo | @ | Western Michigan | MAC | W | 37 | 24 | 2 | 1 | W 2 | |
| 4 | Sep 25, 2010 | Sat | Toledo | @ | Purdue | Big Ten | W | 31 | 20 | 3 | 1 | W 3 | |
| 5 | Oct 2, 2010 | Sat | Toledo | Wyoming | MWC | L | 15 | 20 | 3 | 2 | L 1 | ||
| 6 | Oct 9, 2010 | Sat | Toledo | @ | (4) Boise State | WAC | L | 14 | 57 | 3 | 3 | L 2 | |
| 7 | Oct 16, 2010 | Sat | Toledo | Kent State | MAC | W | 34 | 21 | 4 | 3 | W 1 | ||
| 8 | Oct 23, 2010 | Sat | Toledo | Ball State | MAC | W | 31 | 24 | 5 | 3 | W 2 | ||
| 9 | Oct 30, 2010 | Sat | Toledo | @ | Eastern Michigan | MAC | W | 42 | 7 | 6 | 3 | W 3 | |
| 10 | Nov 9, 2010 | Tue | Toledo | @ | Northern Illinois | MAC | L | 30 | 65 | 6 | 4 | L 1 | |
| 11 | Nov 17, 2010 | Wed | Toledo | Bowling Green | MAC | W | 33 | 14 | 7 | 4 | W 1 | ||
| 12 | Nov 26, 2010 | Fri | Toledo | Central Michigan | MAC | W | 42 | 31 | 8 | 4 | W 2 | ||
| 13 | Dec 26, 2010 | Sun | Toledo | N | Florida International | Sun Belt | L | 32 | 34 | 8 | 5 | L 1 | Little Caesars Bowl (Detroit, MI) |
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