12 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2021 | 7:00 PM | Sat | Syracuse | @ | Ohio | MAC | W | 29 | 9 | 1 | 0 | W 1 | |
| 2 | Sep 11, 2021 | 2:00 PM | Sat | Syracuse | Rutgers | Big Ten | L | 7 | 17 | 1 | 1 | L 1 | ||
| 3 | Sep 18, 2021 | 12:00 PM | Sat | Syracuse | Albany | Non-Major | W | 62 | 24 | 2 | 1 | W 1 | ||
| 4 | Sep 24, 2021 | 8:00 PM | Fri | Syracuse | Liberty | Ind | W | 24 | 21 | 3 | 1 | W 2 | ||
| 5 | Oct 2, 2021 | 3:30 PM | Sat | Syracuse | @ | Florida State | ACC | L | 30 | 33 | 3 | 2 | L 1 | |
| 6 | Oct 9, 2021 | 3:30 PM | Sat | Syracuse | (19) Wake Forest | ACC | L | 37 | 40 | 3 | 3 | L 2 | ||
| 7 | Oct 15, 2021 | 7:00 PM | Fri | Syracuse | Clemson | ACC | L | 14 | 17 | 3 | 4 | L 3 | ||
| 8 | Oct 23, 2021 | 12:30 PM | Sat | Syracuse | @ | Virginia Tech | ACC | W | 41 | 36 | 4 | 4 | W 1 | |
| 9 | Oct 30, 2021 | 3:30 PM | Sat | Syracuse | Boston College | ACC | W | 21 | 6 | 5 | 4 | W 2 | ||
| 10 | Nov 13, 2021 | 12:00 PM | Sat | Syracuse | @ | Louisville | ACC | L | 3 | 41 | 5 | 5 | L 1 | |
| 11 | Nov 20, 2021 | 4:00 PM | Sat | Syracuse | @ | (25) North Carolina State | ACC | L | 17 | 41 | 5 | 6 | L 2 | |
| 12 | Nov 27, 2021 | 7:30 PM | Sat | Syracuse | (20) Pitt | ACC | L | 14 | 31 | 5 | 7 | L 3 |
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