| 1 | Aug 31, 2019 | | Sat | SMU | @ | Arkansas State | Sun Belt | W | 37 | 30 | 1 | 0 | W 1 | Centennial Bank Stadium - Jonesboro, Arkansas |
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| 2 | Sep 7, 2019 | | Sat | SMU | | North Texas | CUSA | W | 49 | 27 | 2 | 0 | W 2 | Gerald J. Ford Stadium - Dallas, Texas |
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| 3 | Sep 14, 2019 | | Sat | SMU | | Texas State | Sun Belt | W | 47 | 17 | 3 | 0 | W 3 | Gerald J. Ford Stadium - Dallas, Texas |
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| 4 | Sep 21, 2019 | | Sat | SMU | @ | (25) Texas Christian | Big 12 | W | 41 | 38 | 4 | 0 | W 4 | Amon G. Carter Stadium - Fort Worth, Texas |
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| 5 | Sep 28, 2019 | | Sat | SMU | @ | South Florida | American | W | 48 | 21 | 5 | 0 | W 5 | Raymond James Stadium - Tampa, Florida |
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| 6 | Oct 5, 2019 | | Sat | (24) SMU | | Tulsa | American | W | 43 | 37 | 6 | 0 | W 6 | Gerald J. Ford Stadium - Dallas, Texas |
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| 7 | Oct 19, 2019 | | Sat | (19) SMU | | Temple | American | W | 45 | 21 | 7 | 0 | W 7 | Gerald J. Ford Stadium - Dallas, Texas |
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| 8 | Oct 24, 2019 | | Thu | (16) SMU | @ | Houston | American | W | 34 | 31 | 8 | 0 | W 8 | TDECU Stadium - Houston, Texas |
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| 9 | Nov 2, 2019 | | Sat | (15) SMU | @ | (24) Memphis | American | L | 48 | 54 | 8 | 1 | L 1 | Liberty Bowl Memorial Stadium - Memphis, Tennessee |
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| 10 | Nov 9, 2019 | | Sat | (23) SMU | | East Carolina | American | W | 59 | 51 | 9 | 1 | W 1 | Gerald J. Ford Stadium - Dallas, Texas |
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| 11 | Nov 23, 2019 | | Sat | (21) SMU | @ | Navy | American | L | 28 | 35 | 9 | 2 | L 1 | Navy-Marine Corps Memorial Stadium - Annapolis, Maryland |
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| 12 | Nov 30, 2019 | | Sat | SMU | | Tulane | American | W | 37 | 20 | 10 | 2 | W 1 | Gerald J. Ford Stadium - Dallas, Texas |
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| 13 | Dec 21, 2019 | | Sat | SMU | N | Florida Atlantic | CUSA | L | 28 | 52 | 10 | 3 | L 1 | Boca Raton Bowl (FAU Football Stadium - Boca Raton, Florida) |
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