14 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 5, 2010 | Sun | SMU | @ | Texas Tech | Big 12 | L | 27 | 35 | 0 | 1 | L 1 | |
| 2 | Sep 11, 2010 | Sat | SMU | UAB | CUSA | W | 28 | 7 | 1 | 1 | W 1 | ||
| 3 | Sep 18, 2010 | Sat | SMU | Washington State | Pac-10 | W | 35 | 21 | 2 | 1 | W 2 | ||
| 4 | Sep 24, 2010 | Fri | SMU | (4) Texas Christian | MWC | L | 24 | 41 | 2 | 2 | L 1 | ||
| 5 | Oct 2, 2010 | Sat | SMU | @ | Rice | CUSA | W | 42 | 31 | 3 | 2 | W 1 | |
| 6 | Oct 9, 2010 | Sat | SMU | Tulsa | CUSA | W | 21 | 18 | 4 | 2 | W 2 | ||
| 7 | Oct 16, 2010 | Sat | SMU | @ | Navy | Ind | L | 21 | 28 | 4 | 3 | L 1 | |
| 8 | Oct 23, 2010 | Sat | SMU | Houston | CUSA | L | 20 | 45 | 4 | 4 | L 2 | ||
| 9 | Oct 30, 2010 | Sat | SMU | @ | Tulane | CUSA | W | 31 | 17 | 5 | 4 | W 1 | |
| 10 | Nov 6, 2010 | Sat | SMU | @ | UTEP | CUSA | L | 14 | 28 | 5 | 5 | L 1 | |
| 11 | Nov 20, 2010 | Sat | SMU | Marshall | CUSA | W | 31 | 17 | 6 | 5 | W 1 | ||
| 12 | Nov 26, 2010 | Fri | SMU | @ | East Carolina | CUSA | W | 45 | 38 | 7 | 5 | W 2 | |
| 13 | Dec 4, 2010 | Sat | SMU | @ | UCF | CUSA | L | 7 | 17 | 7 | 6 | L 1 | CUSA Championship Game |
| 14 | Dec 30, 2010 | Thu | SMU | N | Army | Ind | L | 14 | 16 | 7 | 7 | L 2 | Armed Forces Bowl (Fort Worth, TX) |
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