| 1 | Sep 1, 2019 | 7:30 PM | Sun | (4) Oklahoma | | Houston | American | W | 49 | 31 | 1 | 0 | W 1 | Gaylord Family - Oklahoma Memorial Stadium - Norman, Oklahoma |
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| 2 | Sep 7, 2019 | 7:00 PM | Sat | (4) Oklahoma | | South Dakota | Non-Major | W | 70 | 14 | 2 | 0 | W 2 | Gaylord Family - Oklahoma Memorial Stadium - Norman, Oklahoma |
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| 3 | Sep 14, 2019 | 8:00 PM | Sat | (5) Oklahoma | @ | UCLA | Pac-12 | W | 48 | 14 | 3 | 0 | W 3 | Rose Bowl - Pasadena, California |
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| 4 | Sep 28, 2019 | 12:00 PM | Sat | (6) Oklahoma | | Texas Tech | Big 12 | W | 55 | 16 | 4 | 0 | W 4 | Gaylord Family - Oklahoma Memorial Stadium - Norman, Oklahoma |
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| 5 | Oct 5, 2019 | 12:00 PM | Sat | (6) Oklahoma | @ | Kansas | Big 12 | W | 45 | 20 | 5 | 0 | W 5 | David Booth Kansas Memorial Stadium - Lawrence, Kansas |
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| 6 | Oct 12, 2019 | 12:00 PM | Sat | (6) Oklahoma | N | (11) Texas | Big 12 | W | 34 | 27 | 6 | 0 | W 6 | Cotton Bowl - Dallas, Texas |
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| 7 | Oct 19, 2019 | 12:00 PM | Sat | (5) Oklahoma | | West Virginia | Big 12 | W | 52 | 14 | 7 | 0 | W 7 | Gaylord Family - Oklahoma Memorial Stadium - Norman, Oklahoma |
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| 8 | Oct 26, 2019 | 1:00 PM | Sat | (5) Oklahoma | @ | Kansas State | Big 12 | L | 41 | 48 | 7 | 1 | L 1 | Bill Snyder Family Stadium - Manhattan, Kansas |
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| 9 | Nov 9, 2019 | 8:00 PM | Sat | (9) Oklahoma | | Iowa State | Big 12 | W | 42 | 41 | 8 | 1 | W 1 | Gaylord Family - Oklahoma Memorial Stadium - Norman, Oklahoma |
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| 10 | Nov 16, 2019 | 7:30 PM | Sat | (10) Oklahoma | @ | (12) Baylor | Big 12 | W | 34 | 31 | 9 | 1 | W 2 | McLane Stadium - Waco, Texas |
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| 11 | Nov 23, 2019 | 8:00 PM | Sat | (8) Oklahoma | | Texas Christian | Big 12 | W | 28 | 24 | 10 | 1 | W 3 | Gaylord Family - Oklahoma Memorial Stadium - Norman, Oklahoma |
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| 12 | Nov 30, 2019 | 8:00 PM | Sat | (7) Oklahoma | @ | (21) Oklahoma State | Big 12 | W | 34 | 16 | 11 | 1 | W 4 | Boone Pickens Stadium - Stillwater, Oklahoma |
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| 13 | Dec 7, 2019 | 12:00 PM | Sat | (6) Oklahoma | N | (8) Baylor | Big 12 | W | 30 | 23 | 12 | 1 | W 5 | Big 12 Championship Game |
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| 14 | Dec 28, 2019 | 4:00 PM | Sat | (4) Oklahoma | N | (1) LSU | SEC | L | 28 | 63 | 12 | 2 | L 1 | Peach Bowl (Mercedes-Benz Stadium - Atlanta, Georgia) |
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