13 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2010 | Sat | Ohio | Wofford | Non-Major | W | 33 | 10 | 1 | 0 | W 1 | ||
| 2 | Sep 11, 2010 | Sat | Ohio | Toledo | MAC | L | 13 | 20 | 1 | 1 | L 1 | ||
| 3 | Sep 18, 2010 | Sat | Ohio | @ | (2) Ohio State | Big Ten | L | 7 | 43 | 1 | 2 | L 2 | |
| 4 | Sep 25, 2010 | Sat | Ohio | @ | Marshall | CUSA | L | 23 | 24 | 1 | 3 | L 3 | |
| 5 | Oct 2, 2010 | Sat | Ohio | @ | Eastern Michigan | MAC | W | 30 | 17 | 2 | 3 | W 1 | |
| 6 | Oct 9, 2010 | Sat | Ohio | Bowling Green | MAC | W | 49 | 25 | 3 | 3 | W 2 | ||
| 7 | Oct 16, 2010 | Sat | Ohio | Akron | MAC | W | 38 | 10 | 4 | 3 | W 3 | ||
| 8 | Oct 23, 2010 | Sat | Ohio | @ | Miami (OH) | MAC | W | 34 | 13 | 5 | 3 | W 4 | |
| 9 | Oct 30, 2010 | Sat | Ohio | Louisiana | Sun Belt | W | 38 | 31 | 6 | 3 | W 5 | ||
| 10 | Nov 4, 2010 | Thu | Ohio | Buffalo | MAC | W | 34 | 17 | 7 | 3 | W 6 | ||
| 11 | Nov 16, 2010 | Tue | Ohio | @ | Temple | MAC | W | 31 | 23 | 8 | 3 | W 7 | |
| 12 | Nov 26, 2010 | Fri | Ohio | @ | Kent State | MAC | L | 6 | 28 | 8 | 4 | L 1 | |
| 13 | Dec 18, 2010 | Sat | Ohio | N | Troy | Sun Belt | L | 21 | 48 | 8 | 5 | L 2 | New Orleans Bowl (New Orleans, LA) |
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