13 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2021 | 4:00 PM | Sat | Missouri | Central Michigan | MAC | W | 34 | 24 | 1 | 0 | W 1 | ||
| 2 | Sep 11, 2021 | 7:30 PM | Sat | Missouri | @ | Kentucky | SEC | L | 28 | 35 | 1 | 1 | L 1 | |
| 3 | Sep 18, 2021 | 12:00 PM | Sat | Missouri | Southeast Missouri State | Non-Major | W | 59 | 28 | 2 | 1 | W 1 | ||
| 4 | Sep 25, 2021 | 12:00 PM | Sat | Missouri | @ | Boston College | ACC | L | 34 | 41 | 2 | 2 | L 1 | |
| 5 | Oct 2, 2021 | 12:00 PM | Sat | Missouri | Tennessee | SEC | L | 24 | 62 | 2 | 3 | L 2 | ||
| 6 | Oct 9, 2021 | 4:00 PM | Sat | Missouri | North Texas | CUSA | W | 48 | 35 | 3 | 3 | W 1 | ||
| 7 | Oct 16, 2021 | 12:00 PM | Sat | Missouri | (21) Texas A&M | SEC | L | 14 | 35 | 3 | 4 | L 1 | ||
| 8 | Oct 30, 2021 | 3:00 PM | Sat | Missouri | @ | Vanderbilt | SEC | W | 37 | 28 | 4 | 4 | W 1 | |
| 9 | Nov 6, 2021 | 12:00 PM | Sat | Missouri | @ | (1) Georgia | SEC | L | 6 | 43 | 4 | 5 | L 1 | |
| 10 | Nov 13, 2021 | 4:00 PM | Sat | Missouri | South Carolina | SEC | W | 31 | 28 | 5 | 5 | W 1 | ||
| 11 | Nov 20, 2021 | 4:00 PM | Sat | Missouri | Florida | SEC | W | 24 | 23 | 6 | 5 | W 2 | ||
| 12 | Nov 26, 2021 | 3:30 PM | Fri | Missouri | @ | (25) Arkansas | SEC | L | 17 | 34 | 6 | 6 | L 1 | |
| 13 | Dec 22, 2021 | 8:00 PM | Wed | Missouri | N | Army | Ind | L | 22 | 24 | 6 | 7 | L 2 | Armed Forces Bowl (Amon G. Carter Stadium - Fort Worth, Texas) |
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