| 1 | Sep 1, 2018 | 7:00 PM | Sat | Memphis | | Mercer | Non-Major | W | 66 | 14 | 1 | 0 | W 1 | Liberty Bowl Memorial Stadium - Memphis, Tennessee |
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| 2 | Sep 8, 2018 | 3:30 PM | Sat | Memphis | @ | Navy | American | L | 21 | 22 | 1 | 1 | L 1 | Navy-Marine Corps Memorial Stadium - Annapolis, Maryland |
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| 3 | Sep 14, 2018 | 7:00 PM | Fri | Memphis | | Georgia State | Sun Belt | W | 59 | 22 | 2 | 1 | W 1 | Liberty Bowl Memorial Stadium - Memphis, Tennessee |
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| 4 | Sep 22, 2018 | 8:00 PM | Sat | Memphis | | South Alabama | Sun Belt | W | 52 | 35 | 3 | 1 | W 2 | Liberty Bowl Memorial Stadium - Memphis, Tennessee |
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| 5 | Sep 28, 2018 | 8:00 PM | Fri | Memphis | @ | Tulane | American | L | 24 | 40 | 3 | 2 | L 1 | Yulman Stadium - New Orleans, Louisiana |
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| 6 | Oct 6, 2018 | 7:00 PM | Sat | Memphis | | Connecticut | American | W | 55 | 14 | 4 | 2 | W 1 | Liberty Bowl Memorial Stadium - Memphis, Tennessee |
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| 7 | Oct 13, 2018 | 3:30 PM | Sat | Memphis | | (10) UCF | American | L | 30 | 31 | 4 | 3 | L 1 | Liberty Bowl Memorial Stadium - Memphis, Tennessee |
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| 8 | Oct 20, 2018 | 4:00 PM | Sat | Memphis | @ | Missouri | SEC | L | 33 | 65 | 4 | 4 | L 2 | Memorial Stadium/Faurot Field - Columbia, Missouri |
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| 9 | Nov 3, 2018 | 12:00 PM | Sat | Memphis | @ | East Carolina | American | W | 59 | 41 | 5 | 4 | W 1 | Dowdy-Ficklen Stadium - Greenville, North Carolina |
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| 10 | Nov 10, 2018 | 12:00 PM | Sat | Memphis | | Tulsa | American | W | 47 | 21 | 6 | 4 | W 2 | Liberty Bowl Memorial Stadium - Memphis, Tennessee |
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| 11 | Nov 16, 2018 | 9:00 PM | Fri | Memphis | @ | SMU | American | W | 28 | 18 | 7 | 4 | W 3 | Gerald J. Ford Stadium - Dallas, Texas |
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| 12 | Nov 23, 2018 | 12:00 PM | Fri | Memphis | | Houston | American | W | 52 | 31 | 8 | 4 | W 4 | Liberty Bowl Memorial Stadium - Memphis, Tennessee |
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| 13 | Dec 1, 2018 | 3:30 PM | Sat | Memphis | @ | (7) UCF | American | L | 41 | 56 | 8 | 5 | L 1 | American Championship Game |
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| 14 | Dec 22, 2018 | 12:00 PM | Sat | Memphis | N | Wake Forest | ACC | L | 34 | 37 | 8 | 6 | L 2 | Birmingham Bowl (Legion Field - Birmingham, Alabama) |
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