13 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2010 | Sat | Louisville | Kentucky | SEC | L | 16 | 23 | 0 | 1 | L 1 | ||
| 2 | Sep 11, 2010 | Sat | Louisville | Eastern Kentucky | Non-Major | W | 23 | 13 | 1 | 1 | W 1 | ||
| 3 | Sep 18, 2010 | Sat | Louisville | @ | (25) Oregon State | Pac-10 | L | 28 | 35 | 1 | 2 | L 1 | |
| 4 | Oct 2, 2010 | Sat | Louisville | @ | Arkansas State | Sun Belt | W | 34 | 24 | 2 | 2 | W 1 | |
| 5 | Oct 9, 2010 | Sat | Louisville | Memphis | CUSA | W | 56 | 0 | 3 | 2 | W 2 | ||
| 6 | Oct 15, 2010 | Fri | Louisville | Cincinnati | Big East | L | 27 | 35 | 3 | 3 | L 1 | ||
| 7 | Oct 23, 2010 | Sat | Louisville | Connecticut | Big East | W | 26 | 0 | 4 | 3 | W 1 | ||
| 8 | Oct 30, 2010 | Sat | Louisville | @ | Pitt | Big East | L | 3 | 20 | 4 | 4 | L 1 | |
| 9 | Nov 6, 2010 | Sat | Louisville | @ | Syracuse | Big East | W | 28 | 20 | 5 | 4 | W 1 | |
| 10 | Nov 13, 2010 | Sat | Louisville | South Florida | Big East | L | 21 | 24 | 5 | 5 | L 1 | ||
| 11 | Nov 20, 2010 | Sat | Louisville | West Virginia | Big East | L | 10 | 17 | 5 | 6 | L 2 | ||
| 12 | Nov 26, 2010 | Fri | Louisville | @ | Rutgers | Big East | W | 40 | 13 | 6 | 6 | W 1 | |
| 13 | Dec 21, 2010 | Tue | Louisville | N | Southern Mississippi | CUSA | W | 31 | 28 | 7 | 6 | W 2 | Beef O'Brady's Bowl (St. Petersburg, FL) |
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