11 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | T | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Aug 31, 1991 | Sat | Louisville | Eastern Kentucky | Non-Major | W | 24 | 14 | 1 | 0 | 0 | W 1 | ||
| 2 | Sep 5, 1991 | Thu | Louisville | (11) Tennessee | SEC | L | 11 | 28 | 1 | 1 | 0 | L 1 | ||
| 3 | Sep 14, 1991 | Sat | Louisville | @ | (19) Ohio State | Big Ten | L | 15 | 23 | 1 | 2 | 0 | L 2 | |
| 4 | Sep 28, 1991 | Sat | Louisville | Southern Mississippi | Ind | W | 28 | 14 | 2 | 2 | 0 | W 1 | ||
| 5 | Oct 5, 1991 | Sat | Louisville | Cincinnati | Ind | L | 7 | 30 | 2 | 3 | 0 | L 1 | ||
| 6 | Oct 12, 1991 | Sat | Louisville | @ | Boston College | Big East | L | 3 | 33 | 2 | 4 | 0 | L 2 | |
| 7 | Oct 19, 1991 | Sat | Louisville | Army | Ind | L | 12 | 37 | 2 | 5 | 0 | L 3 | ||
| 8 | Oct 26, 1991 | Sat | Louisville | @ | Virginia Tech | Big East | L | 13 | 41 | 2 | 6 | 0 | L 4 | |
| 9 | Nov 2, 1991 | Sat | Louisville | (1) Florida State | Ind | L | 15 | 40 | 2 | 7 | 0 | L 5 | ||
| 10 | Nov 9, 1991 | Sat | Louisville | @ | Memphis | Ind | L | 7 | 35 | 2 | 8 | 0 | L 6 | |
| 11 | Nov 16, 1991 | Sat | Louisville | @ | Tulsa | Ind | L | 0 | 40 | 2 | 9 | 0 | L 7 |
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