12 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2021 | 12:00 PM | Sat | Louisiana-Monroe | @ | Kentucky | SEC | L | 10 | 45 | 0 | 1 | L 1 | |
| 2 | Sep 18, 2021 | 8:00 PM | Sat | Louisiana-Monroe | Jackson State | Non-Major | W | 12 | 7 | 1 | 1 | W 1 | ||
| 3 | Sep 25, 2021 | 8:00 PM | Sat | Louisiana-Monroe | Troy | Sun Belt | W | 29 | 16 | 2 | 1 | W 2 | ||
| 4 | Oct 2, 2021 | 2:30 PM | Sat | Louisiana-Monroe | @ | (16) Coastal Carolina | Sun Belt | L | 6 | 59 | 2 | 2 | L 1 | |
| 5 | Oct 9, 2021 | 8:00 PM | Sat | Louisiana-Monroe | Georgia State | Sun Belt | L | 21 | 55 | 2 | 3 | L 2 | ||
| 6 | Oct 16, 2021 | 7:00 PM | Sat | Louisiana-Monroe | Liberty | Ind | W | 31 | 28 | 3 | 3 | W 1 | ||
| 7 | Oct 23, 2021 | 7:00 PM | Sat | Louisiana-Monroe | South Alabama | Sun Belt | W | 41 | 31 | 4 | 3 | W 2 | ||
| 8 | Oct 30, 2021 | 3:30 PM | Sat | Louisiana-Monroe | @ | Appalachian State | Sun Belt | L | 28 | 59 | 4 | 4 | L 1 | |
| 9 | Nov 6, 2021 | 3:00 PM | Sat | Louisiana-Monroe | @ | Texas State | Sun Belt | L | 19 | 27 | 4 | 5 | L 2 | |
| 10 | Nov 13, 2021 | 5:00 PM | Sat | Louisiana-Monroe | Arkansas State | Sun Belt | L | 24 | 27 | 4 | 6 | L 3 | ||
| 11 | Nov 20, 2021 | 9:00 PM | Sat | Louisiana-Monroe | @ | LSU | SEC | L | 14 | 27 | 4 | 7 | L 4 | |
| 12 | Nov 27, 2021 | 4:00 PM | Sat | Louisiana-Monroe | @ | (23) Louisiana | Sun Belt | L | 16 | 21 | 4 | 8 | L 5 |
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