12 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Aug 28, 2021 | 1:20 PM | Sat | Illinois | Nebraska | Big Ten | W | 30 | 22 | 1 | 0 | W 1 | ||
| 2 | Sep 4, 2021 | 7:30 PM | Sat | Illinois | UTSA | CUSA | L | 30 | 37 | 1 | 1 | L 1 | ||
| 3 | Sep 11, 2021 | 11:00 AM | Sat | Illinois | @ | Virginia | ACC | L | 14 | 42 | 1 | 2 | L 2 | |
| 4 | Sep 17, 2021 | 9:00 PM | Fri | Illinois | Maryland | Big Ten | L | 17 | 20 | 1 | 3 | L 3 | ||
| 5 | Sep 25, 2021 | 3:30 PM | Sat | Illinois | @ | Purdue | Big Ten | L | 9 | 13 | 1 | 4 | L 4 | |
| 6 | Oct 2, 2021 | 12:00 PM | Sat | Illinois | Charlotte | CUSA | W | 24 | 14 | 2 | 4 | W 1 | ||
| 7 | Oct 9, 2021 | 3:30 PM | Sat | Illinois | Wisconsin | Big Ten | L | 0 | 24 | 2 | 5 | L 1 | ||
| 8 | Oct 23, 2021 | 12:00 PM | Sat | Illinois | @ | (7) Penn State | Big Ten | W | 20 | 18 | 3 | 5 | W 1 | |
| 9 | Oct 30, 2021 | 12:00 PM | Sat | Illinois | Rutgers | Big Ten | L | 14 | 20 | 3 | 6 | L 1 | ||
| 10 | Nov 6, 2021 | 12:00 PM | Sat | Illinois | @ | Minnesota | Big Ten | W | 14 | 6 | 4 | 6 | W 1 | |
| 11 | Nov 20, 2021 | 2:00 PM | Sat | Illinois | @ | (18) Iowa | Big Ten | L | 23 | 33 | 4 | 7 | L 1 | |
| 12 | Nov 27, 2021 | 3:30 PM | Sat | Illinois | Northwestern | Big Ten | W | 47 | 14 | 5 | 7 | W 1 |
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