13 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2010 | Sat | Illinois | N | Missouri | Big 12 | L | 13 | 23 | 0 | 1 | L 1 | |
| 2 | Sep 11, 2010 | Sat | Illinois | Southern Illinois | Non-Major | W | 35 | 3 | 1 | 1 | W 1 | ||
| 3 | Sep 18, 2010 | Sat | Illinois | Northern Illinois | MAC | W | 28 | 22 | 2 | 1 | W 2 | ||
| 4 | Oct 2, 2010 | Sat | Illinois | (2) Ohio State | Big Ten | L | 13 | 24 | 2 | 2 | L 1 | ||
| 5 | Oct 9, 2010 | Sat | Illinois | @ | Penn State | Big Ten | W | 33 | 13 | 3 | 2 | W 1 | |
| 6 | Oct 16, 2010 | Sat | Illinois | @ | (13) Michigan State | Big Ten | L | 6 | 26 | 3 | 3 | L 1 | |
| 7 | Oct 23, 2010 | Sat | Illinois | Indiana | Big Ten | W | 43 | 13 | 4 | 3 | W 1 | ||
| 8 | Oct 30, 2010 | Sat | Illinois | Purdue | Big Ten | W | 44 | 10 | 5 | 3 | W 2 | ||
| 9 | Nov 6, 2010 | Sat | Illinois | @ | Michigan | Big Ten | L | 65 | 67 | 5 | 4 | L 1 | |
| 10 | Nov 13, 2010 | Sat | Illinois | Minnesota | Big Ten | L | 34 | 38 | 5 | 5 | L 2 | ||
| 11 | Nov 20, 2010 | Sat | Illinois | @ | Northwestern | Big Ten | W | 48 | 27 | 6 | 5 | W 1 | |
| 12 | Dec 3, 2010 | Fri | Illinois | @ | Fresno State | WAC | L | 23 | 25 | 6 | 6 | L 1 | |
| 13 | Dec 29, 2010 | Wed | Illinois | N | Baylor | Big 12 | W | 38 | 14 | 7 | 6 | W 1 | Texas Bowl (Houston, TX) |
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