AP Poll Summary
| Pre | 9/7 | 9/13 | 9/19 | 9/26 | 10/3 | 10/10 | 10/17 | 10/24 | 10/31 | 11/7 | 11/14 | 11/21 | 11/28 | 12/5 | Final |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 20 | 17 | 17 | 19 | 16 | 21 | 17 |
14 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2021 | 7:00 PM | Sat | Houston | N | Texas Tech | Big 12 | L | 21 | 38 | 0 | 1 | L 1 | NRG Stadium - Houston, Texas |
| 2 | Sep 11, 2021 | 6:30 PM | Sat | Houston | @ | Rice | CUSA | W | 44 | 7 | 1 | 1 | W 1 | |
| 3 | Sep 18, 2021 | 7:00 PM | Sat | Houston | Grambling State | Non-Major | W | 45 | 0 | 2 | 1 | W 2 | ||
| 4 | Sep 25, 2021 | 7:00 PM | Sat | Houston | Navy | American | W | 28 | 20 | 3 | 1 | W 3 | ||
| 5 | Oct 1, 2021 | 6:35 PM | Fri | Houston | @ | Tulsa | American | W | 45 | 10 | 4 | 1 | W 4 | |
| 6 | Oct 7, 2021 | 7:30 PM | Thu | Houston | @ | Tulane | American | W | 40 | 22 | 5 | 1 | W 5 | |
| 7 | Oct 23, 2021 | 4:00 PM | Sat | Houston | East Carolina | American | W | 31 | 24 | 6 | 1 | W 6 | ||
| 8 | Oct 30, 2021 | 7:00 PM | Sat | Houston | (19) SMU | American | W | 44 | 37 | 7 | 1 | W 7 | ||
| 9 | Nov 6, 2021 | 7:30 PM | Sat | (20) Houston | @ | South Florida | American | W | 54 | 42 | 8 | 1 | W 8 | |
| 10 | Nov 13, 2021 | 12:00 PM | Sat | (17) Houston | @ | Temple | American | W | 37 | 8 | 9 | 1 | W 9 | |
| 11 | Nov 19, 2021 | 9:00 PM | Fri | (17) Houston | Memphis | American | W | 31 | 13 | 10 | 1 | W 10 | ||
| 12 | Nov 27, 2021 | 12:00 PM | Sat | (19) Houston | @ | Connecticut | Ind | W | 45 | 17 | 11 | 1 | W 11 | |
| 13 | Dec 4, 2021 | 4:00 PM | Sat | (16) Houston | @ | (3) Cincinnati | American | L | 20 | 35 | 11 | 2 | L 1 | American Championship Game |
| 14 | Dec 28, 2021 | 12:00 PM | Tue | (21) Houston | N | Auburn | SEC | W | 17 | 13 | 12 | 2 | W 1 | Birmingham Bowl (Protective Stadium - Birmingham, Alabama) |
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