12 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2010 | Sat | Eastern Michigan | Army | Ind | L | 27 | 31 | 0 | 1 | L 1 | ||
| 2 | Sep 11, 2010 | Sat | Eastern Michigan | @ | Miami (OH) | MAC | L | 21 | 28 | 0 | 2 | L 2 | |
| 3 | Sep 18, 2010 | Sat | Eastern Michigan | Central Michigan | MAC | L | 14 | 52 | 0 | 3 | L 3 | ||
| 4 | Sep 25, 2010 | Sat | Eastern Michigan | @ | (2) Ohio State | Big Ten | L | 20 | 73 | 0 | 4 | L 4 | |
| 5 | Oct 2, 2010 | Sat | Eastern Michigan | Ohio | MAC | L | 17 | 30 | 0 | 5 | L 5 | ||
| 6 | Oct 9, 2010 | Sat | Eastern Michigan | @ | Vanderbilt | SEC | L | 6 | 52 | 0 | 6 | L 6 | |
| 7 | Oct 16, 2010 | Sat | Eastern Michigan | @ | Ball State | MAC | W | 41 | 38 | 1 | 6 | W 1 | |
| 8 | Oct 23, 2010 | Sat | Eastern Michigan | @ | Virginia | ACC | L | 21 | 48 | 1 | 7 | L 1 | |
| 9 | Oct 30, 2010 | Sat | Eastern Michigan | Toledo | MAC | L | 7 | 42 | 1 | 8 | L 2 | ||
| 10 | Nov 13, 2010 | Sat | Eastern Michigan | @ | Western Michigan | MAC | L | 30 | 45 | 1 | 9 | L 3 | |
| 11 | Nov 20, 2010 | Sat | Eastern Michigan | @ | Buffalo | MAC | W | 21 | 17 | 2 | 9 | W 1 | |
| 12 | Nov 26, 2010 | Fri | Eastern Michigan | Northern Illinois | MAC | L | 3 | 71 | 2 | 10 | L 1 |
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