12 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2010 | Sat | Duke | Elon | Non-Major | W | 41 | 27 | 1 | 0 | W 1 | ||
| 2 | Sep 11, 2010 | Sat | Duke | @ | Wake Forest | ACC | L | 48 | 54 | 1 | 1 | L 1 | |
| 3 | Sep 18, 2010 | Sat | Duke | (1) Alabama | SEC | L | 13 | 62 | 1 | 2 | L 2 | ||
| 4 | Sep 25, 2010 | Sat | Duke | Army | Ind | L | 21 | 35 | 1 | 3 | L 3 | ||
| 5 | Oct 2, 2010 | Sat | Duke | @ | Maryland | ACC | L | 16 | 21 | 1 | 4 | L 4 | |
| 6 | Oct 16, 2010 | Sat | Duke | Miami (FL) | ACC | L | 13 | 28 | 1 | 5 | L 5 | ||
| 7 | Oct 23, 2010 | Sat | Duke | @ | (23) Virginia Tech | ACC | L | 7 | 44 | 1 | 6 | L 6 | |
| 8 | Oct 30, 2010 | Sat | Duke | @ | Navy | Ind | W | 34 | 31 | 2 | 6 | W 1 | |
| 9 | Nov 6, 2010 | Sat | Duke | Virginia | ACC | W | 55 | 48 | 3 | 6 | W 2 | ||
| 10 | Nov 13, 2010 | Sat | Duke | Boston College | ACC | L | 16 | 21 | 3 | 7 | L 1 | ||
| 11 | Nov 20, 2010 | Sat | Duke | @ | Georgia Tech | ACC | L | 20 | 30 | 3 | 8 | L 2 | |
| 12 | Nov 27, 2010 | Sat | Duke | North Carolina | ACC | L | 19 | 24 | 3 | 9 | L 3 |
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