| 1 | Aug 29, 2019 | | Thu | (1) Clemson | | Georgia Tech | ACC | W | 52 | 14 | 1 | 0 | W 1 | Clemson Memorial Stadium - Clemson, South Carolina |
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| 2 | Sep 7, 2019 | | Sat | (1) Clemson | | (12) Texas A&M | SEC | W | 24 | 10 | 2 | 0 | W 2 | Clemson Memorial Stadium - Clemson, South Carolina |
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| 3 | Sep 14, 2019 | | Sat | (1) Clemson | @ | Syracuse | ACC | W | 41 | 6 | 3 | 0 | W 3 | Carrier Dome - Syracuse, New York |
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| 4 | Sep 21, 2019 | | Sat | (1) Clemson | | Charlotte | CUSA | W | 52 | 10 | 4 | 0 | W 4 | Clemson Memorial Stadium - Clemson, South Carolina |
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| 5 | Sep 28, 2019 | | Sat | (1) Clemson | @ | North Carolina | ACC | W | 21 | 20 | 5 | 0 | W 5 | Kenan Memorial Stadium - Chapel Hill, North Carolina |
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| 6 | Oct 12, 2019 | | Sat | (2) Clemson | | Florida State | ACC | W | 45 | 14 | 6 | 0 | W 6 | Clemson Memorial Stadium - Clemson, South Carolina |
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| 7 | Oct 19, 2019 | | Sat | (3) Clemson | @ | Louisville | ACC | W | 45 | 10 | 7 | 0 | W 7 | Cardinal Stadium - Louisville, Kentucky |
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| 8 | Oct 26, 2019 | | Sat | (4) Clemson | | Boston College | ACC | W | 59 | 7 | 8 | 0 | W 8 | Clemson Memorial Stadium - Clemson, South Carolina |
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| 9 | Nov 2, 2019 | | Sat | (4) Clemson | | Wofford | Non-Major | W | 59 | 14 | 9 | 0 | W 9 | Clemson Memorial Stadium - Clemson, South Carolina |
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| 10 | Nov 9, 2019 | | Sat | (4) Clemson | @ | North Carolina State | ACC | W | 55 | 10 | 10 | 0 | W 10 | Carter-Finley Stadium - Raleigh, North Carolina |
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| 11 | Nov 16, 2019 | | Sat | (3) Clemson | | Wake Forest | ACC | W | 52 | 3 | 11 | 0 | W 11 | Clemson Memorial Stadium - Clemson, South Carolina |
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| 12 | Nov 30, 2019 | | Sat | (3) Clemson | @ | South Carolina | SEC | W | 38 | 3 | 12 | 0 | W 12 | Williams-Brice Stadium - Columbia, South Carolina |
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| 13 | Dec 7, 2019 | | Sat | (3) Clemson | N | (22) Virginia | ACC | W | 62 | 17 | 13 | 0 | W 13 | ACC Championship Game |
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| 14 | Dec 28, 2019 | | Sat | (3) Clemson | N | (2) Ohio State | Big Ten | W | 29 | 23 | 14 | 0 | W 14 | Fiesta Bowl (State Farm Stadium - Glendale, Arizona) |
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| 15 | Jan 13, 2020 | | Mon | (3) Clemson | N | (1) LSU | SEC | L | 25 | 42 | 14 | 1 | L 1 | College Football Playoff National Championship (Mercedes-Benz Superdome - New Orleans, Louisiana) |
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