13 Games
| G | Date | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 4, 2010 | Sat | Clemson | North Texas | Sun Belt | W | 35 | 10 | 1 | 0 | W 1 | ||
| 2 | Sep 11, 2010 | Sat | Clemson | Presbyterian | Non-Major | W | 58 | 21 | 2 | 0 | W 2 | ||
| 3 | Sep 18, 2010 | Sat | Clemson | @ | (16) Auburn | SEC | L | 24 | 27 | 2 | 1 | L 1 | |
| 4 | Oct 2, 2010 | Sat | Clemson | (16) Miami (FL) | ACC | L | 21 | 30 | 2 | 2 | L 2 | ||
| 5 | Oct 9, 2010 | Sat | Clemson | @ | North Carolina | ACC | L | 16 | 21 | 2 | 3 | L 3 | |
| 6 | Oct 16, 2010 | Sat | Clemson | Maryland | ACC | W | 31 | 7 | 3 | 3 | W 1 | ||
| 7 | Oct 23, 2010 | Sat | Clemson | Georgia Tech | ACC | W | 27 | 13 | 4 | 3 | W 2 | ||
| 8 | Oct 30, 2010 | Sat | Clemson | @ | Boston College | ACC | L | 10 | 16 | 4 | 4 | L 1 | |
| 9 | Nov 6, 2010 | Sat | Clemson | (23) North Carolina State | ACC | W | 14 | 13 | 5 | 4 | W 1 | ||
| 10 | Nov 13, 2010 | Sat | Clemson | @ | Florida State | ACC | L | 13 | 16 | 5 | 5 | L 1 | |
| 11 | Nov 20, 2010 | Sat | Clemson | @ | Wake Forest | ACC | W | 30 | 10 | 6 | 5 | W 1 | |
| 12 | Nov 27, 2010 | Sat | Clemson | (18) South Carolina | SEC | L | 7 | 29 | 6 | 6 | L 1 | ||
| 13 | Dec 31, 2010 | Fri | Clemson | N | South Florida | Big East | L | 26 | 31 | 6 | 7 | L 2 | Meineke Car Care Bowl (Charlotte, NC) |
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