12 Games
| G | Date | Time | Day | School | Opponent | Conf | Pts | Opp | W | L | Streak | Notes | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | Sep 3, 2021 | 7:00 PM | Fri | Charlotte | Duke | ACC | W | 31 | 28 | 1 | 0 | W 1 | ||
| 2 | Sep 11, 2021 | 6:00 PM | Sat | Charlotte | Gardner-Webb | Non-Major | W | 38 | 10 | 2 | 0 | W 2 | ||
| 3 | Sep 18, 2021 | 7:00 PM | Sat | Charlotte | @ | Georgia State | Sun Belt | L | 9 | 20 | 2 | 1 | L 1 | |
| 4 | Sep 24, 2021 | 6:30 PM | Fri | Charlotte | Middle Tennessee State | CUSA | W | 42 | 39 | 3 | 1 | W 1 | ||
| 5 | Oct 2, 2021 | 12:00 PM | Sat | Charlotte | @ | Illinois | Big Ten | L | 14 | 24 | 3 | 2 | L 1 | |
| 6 | Oct 8, 2021 | 7:00 PM | Fri | Charlotte | @ | Florida International | CUSA | W | 45 | 33 | 4 | 2 | W 1 | |
| 7 | Oct 21, 2021 | 7:30 PM | Thu | Charlotte | Florida Atlantic | CUSA | L | 9 | 38 | 4 | 3 | L 1 | ||
| 8 | Oct 30, 2021 | 4:00 PM | Sat | Charlotte | @ | Western Kentucky | CUSA | L | 13 | 45 | 4 | 4 | L 2 | |
| 9 | Nov 6, 2021 | 3:30 PM | Sat | Charlotte | Rice | CUSA | W | 31 | 24 | 5 | 4 | W 1 | ||
| 10 | Nov 13, 2021 | 3:30 PM | Sat | Charlotte | @ | Louisiana Tech | CUSA | L | 32 | 42 | 5 | 5 | L 1 | |
| 11 | Nov 20, 2021 | 3:30 PM | Sat | Charlotte | Marshall | CUSA | L | 28 | 49 | 5 | 6 | L 2 | ||
| 12 | Nov 27, 2021 | 2:00 PM | Sat | Charlotte | @ | Old Dominion | CUSA | L | 34 | 56 | 5 | 7 | L 3 |
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