| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 23 | 5 | 2021-10-02 | Louisville | @ | Wake Forest | REG (Conf) | L 34-37 |
| 2 | 24 | 8 | 2021-10-30 | Louisville | @ | North Carolina State | REG (Conf) | L 13-28 |
| 3 | 25 | 10 | 2021-11-13 | Louisville | Syracuse | REG (Conf) | W 41-3 | |
| 4 | 26 | 11 | 2021-11-18 | Louisville | @ | Duke | REG (Conf) | W 62-22 |
| 5 | 27 | 12 | 2021-11-27 | Louisville | Kentucky | REG (Non-Conf) | L 21-52 | |
| 2-3 |
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