| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 34 | 1 | 2022-09-05 | Clemson | @ | Georgia Tech | REG (Conf) | W 41-10 | |
| 2 | 35 | 2 | 2022-09-10 | Clemson | Furman | REG (Non-Conf) | W 35-12 | ||
| 3 | 36 | 3 | 2022-09-17 | Clemson | Louisiana Tech | REG (Non-Conf) | W 48-20 | ||
| 4 | 37 | 4 | 2022-09-24 | Clemson | @ | Wake Forest | REG (Conf) | W 51-45 (2OT) | |
| 5 | 38 | 5 | 2022-10-01 | Clemson | North Carolina State | REG (Conf) | W 30-20 | ||
| 6 | 39 | 6 | 2022-10-08 | Clemson | @ | Boston College | REG (Conf) | W 31-3 | |
| 7 | 40 | 7 | 2022-10-15 | Clemson | @ | Florida State | REG (Conf) | W 34-28 | |
| 8 | 41 | 8 | 2022-10-22 | Clemson | Syracuse | REG (Conf) | W 27-21 | ||
| 9 | 42 | 9 | 2022-11-05 | Clemson | @ | Notre Dame | REG (Non-Conf) | L 14-35 | |
| 10 | 43 | 10 | 2022-11-12 | Clemson | Louisville | REG (Conf) | W 31-16 | ||
| 11 | 44 | 11 | 2022-11-19 | Clemson | Miami (FL) | REG (Conf) | W 40-10 | ||
| 12 | 45 | 12 | 2022-11-26 | Clemson | South Carolina | REG (Non-Conf) | L 30-31 | ||
| 13 | 46 | 13 | 2022-12-03 | Clemson | N | North Carolina | Conf Championship | W 39-10 | |
| 14 | 47 | 14 | 2022-12-30 | Clemson | N | Tennessee | Bowl | L 14-31 | Orange Bowl |
| 11-3 |
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