| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 13 | 1 | 2016-09-03 | Clemson | @ | Auburn | REG (Non-Conf) | W 19-13 | |
| 2 | 14 | 2 | 2016-09-10 | Clemson | Troy | REG (Non-Conf) | W 30-24 | ||
| 3 | 15 | 3 | 2016-09-17 | Clemson | South Carolina St. | REG (Non-Conf) | W 59-0 | ||
| 4 | 16 | 5 | 2016-10-01 | Clemson | Louisville | REG (Conf) | W 42-36 | ||
| 5 | 17 | 6 | 2016-10-07 | Clemson | @ | Boston College | REG (Conf) | W 56-10 | |
| 6 | 18 | 7 | 2016-10-15 | Clemson | North Carolina State | REG (Conf) | W 24-17 (OT) | ||
| 7 | 19 | 9 | 2016-11-05 | Clemson | Syracuse | REG (Conf) | W 54-0 | ||
| 8 | 20 | 10 | 2016-11-12 | Clemson | Pitt | REG (Conf) | L 42-43 | ||
| 9 | 21 | 11 | 2016-11-19 | Clemson | @ | Wake Forest | REG (Conf) | W 35-13 | |
| 10 | 22 | 12 | 2016-11-26 | Clemson | South Carolina | REG (Non-Conf) | W 56-7 | ||
| 11 | 23 | 13 | 2016-12-03 | Clemson | N | Virginia Tech | Conf Championship | W 42-35 | |
| 12 | 24 | 14 | 2016-12-31 | Clemson | N | Ohio State | CFB Semifinal | W 31-0 | Fiesta Bowl |
| 13 | 25 | 15 | 2017-01-09 | Clemson | N | Alabama | CFB Championship | W 35-31 | College Football Playoff National Championship |
| 12-1 |
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