| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 1 | 2021-09-04 | Michigan | Western Michigan | REG (Non-Conf) | W 47-14 | ||
| 2 | 2 | 2 | 2021-09-11 | Michigan | Washington | REG (Non-Conf) | W 31-10 | ||
| 3 | 3 | 3 | 2021-09-18 | Michigan | Northern Illinois | REG (Non-Conf) | W 63-10 | ||
| 4 | 4 | 4 | 2021-09-25 | Michigan | Rutgers | REG (Conf) | W 20-13 | ||
| 5 | 5 | 5 | 2021-10-02 | Michigan | @ | Wisconsin | REG (Conf) | W 38-17 | |
| 6 | 6 | 6 | 2021-10-09 | Michigan | @ | Nebraska | REG (Conf) | W 32-29 | |
| 7 | 7 | 7 | 2021-10-23 | Michigan | Northwestern | REG (Conf) | W 33-7 | ||
| 8 | 8 | 8 | 2021-10-30 | Michigan | @ | Michigan State | REG (Conf) | L 33-37 | |
| 9 | 9 | 9 | 2021-11-06 | Michigan | Indiana | REG (Conf) | W 29-7 | ||
| 10 | 10 | 10 | 2021-11-13 | Michigan | @ | Penn State | REG (Conf) | W 21-17 | |
| 11 | 11 | 11 | 2021-11-20 | Michigan | @ | Maryland | REG (Conf) | W 59-18 | |
| 12 | 12 | 12 | 2021-11-27 | Michigan | Ohio State | REG (Conf) | W 42-27 | ||
| 13 | 13 | 13 | 2021-12-04 | Michigan | N | Iowa | Conf Championship | W 42-3 | |
| 14 | 14 | 14 | 2021-12-31 | Michigan | N | Georgia | CFB Semifinal | L 11-34 | Orange Bowl |
| 12-2 |
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