| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 7 | 1 | 2021-09-03 | Wake Forest | Old Dominion | REG (Non-Conf) | W 42-10 | ||
| 2 | 8 | 3 | 2021-09-18 | Wake Forest | Florida State | REG (Conf) | W 35-14 | ||
| 3 | 9 | 4 | 2021-09-24 | Wake Forest | @ | Virginia | REG (Conf) | W 37-17 | |
| 4 | 10 | 5 | 2021-10-02 | Wake Forest | Louisville | REG (Conf) | W 37-34 | ||
| 5 | 11 | 6 | 2021-10-09 | Wake Forest | @ | Syracuse | REG (Conf) | W 40-37 | |
| 6 | 12 | 7 | 2021-10-23 | Wake Forest | @ | Army | REG (Non-Conf) | W 70-56 | |
| 7 | 13 | 8 | 2021-10-30 | Wake Forest | Duke | REG (Conf) | W 45-7 | ||
| 8 | 14 | 9 | 2021-11-06 | Wake Forest | @ | North Carolina | REG (Non-Conf) | L 55-58 | |
| 9 | 15 | 10 | 2021-11-13 | Wake Forest | North Carolina State | REG (Conf) | W 45-42 | ||
| 10 | 16 | 11 | 2021-11-20 | Wake Forest | @ | Clemson | REG (Conf) | L 27-48 | |
| 11 | 17 | 12 | 2021-11-27 | Wake Forest | @ | Boston College | REG (Conf) | W 41-10 | |
| 12 | 18 | 13 | 2021-12-04 | Wake Forest | N | Pitt | Conf Championship | L 21-45 | |
| 13 | 19 | 14 | 2021-12-31 | Wake Forest | N | Rutgers | Bowl | W 38-10 | Gator Bowl |
| 10-3 |
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