| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 11 | 1 | 2022-09-02 | Michigan State | Western Michigan | REG (Non-Conf) | W 35-13 | |
| 2 | 12 | 2 | 2022-09-10 | Michigan State | Akron | REG (Non-Conf) | W 52-0 | |
| 3 | 13 | 3 | 2022-09-17 | Michigan State | @ | Washington | REG (Non-Conf) | L 28-39 |
| 4 | 14 | 4 | 2022-09-24 | Michigan State | Minnesota | REG (Conf) | L 7-34 | |
| 5 | 15 | 5 | 2022-10-01 | Michigan State | @ | Maryland | REG (Conf) | L 13-27 |
| 6 | 16 | 6 | 2022-10-08 | Michigan State | Ohio State | REG (Conf) | L 20-49 | |
| 7 | 17 | 7 | 2022-10-15 | Michigan State | Wisconsin | REG (Conf) | W 34-28 (2OT) | |
| 8 | 18 | 8 | 2022-10-29 | Michigan State | @ | Michigan | REG (Conf) | L 7-29 |
| 9 | 19 | 9 | 2022-11-05 | Michigan State | @ | Illinois | REG (Conf) | W 23-15 |
| 10 | 20 | 10 | 2022-11-12 | Michigan State | Rutgers | REG (Conf) | W 27-21 | |
| 11 | 21 | 11 | 2022-11-19 | Michigan State | Indiana | REG (Conf) | L 31-39 (2OT) | |
| 12 | 22 | 12 | 2022-11-26 | Michigan State | @ | Penn State | REG (Conf) | L 16-35 |
| 5-7 |
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