| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 29 | 1 | 2021-09-04 | Louisiana | @ | Texas | REG (Non-Conf) | L 18-38 | |
| 2 | 30 | 2 | 2021-09-11 | Louisiana | Nicholls St. | REG (Non-Conf) | W 27-24 | ||
| 3 | 31 | 3 | 2021-09-16 | Louisiana | Ohio | REG (Non-Conf) | W 49-14 | ||
| 4 | 32 | 4 | 2021-09-25 | Louisiana | @ | Georgia Southern | REG (Conf) | W 28-20 | |
| 5 | 33 | 5 | 2021-10-02 | Louisiana | @ | South Alabama | REG (Conf) | W 20-18 | |
| 6 | 34 | 7 | 2021-10-21 | Louisiana | @ | Arkansas State | REG (Conf) | W 28-27 | |
| 7 | 35 | 8 | 2021-10-30 | Louisiana | Texas State | REG (Conf) | W 45-0 | ||
| 8 | 36 | 9 | 2021-11-04 | Louisiana | Georgia State | REG (Conf) | W 21-17 | ||
| 9 | 37 | 10 | 2021-11-13 | Louisiana | @ | Troy | REG (Conf) | W 35-21 | |
| 10 | 38 | 11 | 2021-11-20 | Louisiana | @ | Liberty | REG (Non-Conf) | W 42-14 | |
| 11 | 39 | 13 | 2021-12-04 | Louisiana | Appalachian State | Conf Championship | W 24-16 | ||
| 12 | 40 | 14 | 2021-12-18 | Louisiana | N | Marshall | Bowl | W 36-21 | New Orleans Bowl |
| 11-1 |
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