| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 1 | 2022-09-03 | Louisville | @ | Syracuse | REG (Conf) | L 7-31 | |
| 2 | 3 | 2 | 2022-09-09 | Louisville | @ | UCF | REG (Non-Conf) | W 20-14 | |
| 3 | 4 | 3 | 2022-09-16 | Louisville | Florida State | REG (Conf) | L 31-35 | ||
| 4 | 5 | 4 | 2022-09-24 | Louisville | South Florida | REG (Non-Conf) | W 41-3 | ||
| 5 | 6 | 5 | 2022-10-01 | Louisville | @ | Boston College | REG (Conf) | L 33-34 | |
| 6 | 7 | 6 | 2022-10-08 | Louisville | @ | Virginia | REG (Conf) | W 34-17 | |
| 7 | 8 | 7 | 2022-10-22 | Louisville | Pitt | REG (Conf) | W 24-10 | ||
| 8 | 9 | 8 | 2022-10-29 | Louisville | Wake Forest | REG (Conf) | W 48-21 | ||
| 9 | 10 | 9 | 2022-11-05 | Louisville | James Madison | REG (Non-Conf) | W 34-10 | ||
| 10 | 11 | 10 | 2022-11-12 | Louisville | @ | Clemson | REG (Conf) | L 16-31 | |
| 11 | 12 | 11 | 2022-11-19 | Louisville | North Carolina State | REG (Conf) | W 25-10 | ||
| 12 | 13 | 12 | 2022-11-26 | Louisville | @ | Kentucky | REG (Non-Conf) | L 13-26 | |
| 13 | 14 | 13 | 2022-12-17 | Louisville | N | Cincinnati | Bowl | W 24-7 | Fenway Bowl |
| 8-5 |
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