| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 20 | 1 | 2021-09-04 | Mississippi State | Louisiana Tech | REG (Non-Conf) | W 35-34 | |
| 2 | 21 | 2 | 2021-09-11 | Mississippi State | North Carolina State | REG (Non-Conf) | W 24-10 | |
| 3 | 22 | 3 | 2021-09-18 | Mississippi State | @ | Memphis | REG (Non-Conf) | L 29-31 |
| 4 | 23 | 4 | 2021-09-25 | Mississippi State | LSU | REG (Conf) | L 25-28 | |
| 5 | 24 | 5 | 2021-10-02 | Mississippi State | @ | Texas A&M | REG (Conf) | W 26-22 |
| 6 | 25 | 6 | 2021-10-16 | Mississippi State | Alabama | REG (Conf) | L 9-49 | |
| 7 | 26 | 7 | 2021-10-23 | Mississippi State | @ | Vanderbilt | REG (Conf) | W 45-6 |
| 8 | 27 | 8 | 2021-10-30 | Mississippi State | Kentucky | REG (Conf) | W 31-17 | |
| 9 | 28 | 9 | 2021-11-06 | Mississippi State | @ | Arkansas | REG (Conf) | L 28-31 |
| 10 | 29 | 10 | 2021-11-13 | Mississippi State | @ | Auburn | REG (Conf) | W 43-34 |
| 11 | 30 | 11 | 2021-11-20 | Mississippi State | Tennessee St. | REG (Non-Conf) | W 55-10 | |
| 12 | 31 | 12 | 2021-11-25 | Mississippi State | Ole Miss | REG (Conf) | L 21-31 | |
| 7-5 |
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