| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 3 | 1 | 2021-09-04 | Wyoming | Montana St. | REG (Non-Conf) | W 19-16 | ||
| 2 | 4 | 2 | 2021-09-11 | Wyoming | @ | Northern Illinois | REG (Non-Conf) | W 50-43 | |
| 3 | 5 | 3 | 2021-09-18 | Wyoming | Ball State | REG (Non-Conf) | W 45-12 | ||
| 4 | 6 | 4 | 2021-09-25 | Wyoming | @ | Connecticut | REG (Non-Conf) | W 24-22 | |
| 5 | 7 | 5 | 2021-10-09 | Wyoming | @ | Air Force | REG (Conf) | L 14-24 | |
| 6 | 8 | 6 | 2021-10-16 | Wyoming | Fresno State | REG (Conf) | L 0-17 | ||
| 7 | 9 | 7 | 2021-10-23 | Wyoming | New Mexico | REG (Conf) | L 3-14 | ||
| 8 | 10 | 8 | 2021-10-30 | Wyoming | @ | San Jose State | REG (Conf) | L 21-27 | |
| 9 | 11 | 9 | 2021-11-06 | Wyoming | Colorado State | REG (Conf) | W 31-17 | ||
| 10 | 12 | 10 | 2021-11-12 | Wyoming | @ | Boise State | REG (Conf) | L 13-23 | |
| 11 | 13 | 11 | 2021-11-20 | Wyoming | @ | Utah State | REG (Conf) | W 44-17 | |
| 12 | 14 | 12 | 2021-11-27 | Wyoming | Hawaii | REG (Conf) | L 14-38 | ||
| 13 | 15 | 13 | 2021-12-21 | Wyoming | N | Kent State | Bowl | W 52-38 | Famous Idaho Potato Bowl |
| 7-6 |
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