| Rk | Date | School | Opponent | ||
|---|---|---|---|---|---|
| 1 | 2021-09-04 | Indiana | @ | Iowa | L |
| 2 | 2021-09-11 | Indiana | Idaho | W | |
| 3 | 2021-09-18 | Indiana | Cincinnati | L | |
| 4 | 2021-09-25 | Indiana | @ | Western Kentucky | W |
| 5 | 2021-10-02 | Indiana | @ | Penn State | L |
| 6 | 2021-10-16 | Indiana | Michigan State | L | |
| 7 | 2021-10-23 | Indiana | Ohio State | L | |
| 8 | 2021-11-06 | Indiana | @ | Michigan | L |
| 9 | 2021-11-13 | Indiana | Rutgers | L | |
| 10 | 2021-11-20 | Indiana | Minnesota | L | |
| 11 | 2021-11-27 | Indiana | @ | Purdue | L |
| 11 Games | |||||
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