| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 1 | 2021-09-02 | Buffalo | Wagner | REG (Non-Conf) | W 69-7 | |
| 2 | 2 | 2 | 2021-09-11 | Buffalo | @ | Nebraska | REG (Non-Conf) | L 3-28 |
| 3 | 3 | 3 | 2021-09-18 | Buffalo | Coastal Carolina | REG (Non-Conf) | L 25-28 | |
| 4 | 4 | 4 | 2021-09-25 | Buffalo | @ | Old Dominion | REG (Non-Conf) | W 35-34 |
| 2-2 |
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