| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 1 | 2022-09-03 | Buffalo | @ | Maryland | REG (Non-Conf) | L 10-31 |
| 2 | 2 | 3 | 2022-09-17 | Buffalo | @ | Coastal Carolina | REG (Non-Conf) | L 26-38 |
| 3 | 3 | 4 | 2022-09-24 | Buffalo | @ | Eastern Michigan | REG (Conf) | W 50-31 |
| 4 | 4 | 5 | 2022-10-01 | Buffalo | Miami (OH) | REG (Conf) | W 24-20 | |
| 5 | 5 | 6 | 2022-10-08 | Buffalo | @ | Bowling Green | REG (Conf) | W 38-7 |
| 6 | 6 | 8 | 2022-10-22 | Buffalo | Toledo | REG (Conf) | W 34-27 | |
| 7 | 7 | 9 | 2022-11-01 | Buffalo | @ | Ohio | REG (Conf) | L 24-45 |
| 8 | 8 | 10 | 2022-11-09 | Buffalo | @ | Central Michigan | REG (Conf) | L 27-31 |
| 9 | 9 | 11 | 2022-11-26 | Buffalo | Kent State | REG (Conf) | L 27-30 (OT) | |
| 10 | 10 | 12 | 2022-12-02 | Buffalo | Akron | REG (Conf) | W 23-22 | |
| 5-5 |
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