| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 13 | 1 | 2022-09-05 | Clemson | @ | Georgia Tech | REG (Conf) | W 41-10 | |
| 2 | 14 | 2 | 2022-09-10 | Clemson | Furman | REG (Non-Conf) | W 35-12 | ||
| 3 | 15 | 3 | 2022-09-17 | Clemson | Louisiana Tech | REG (Non-Conf) | W 48-20 | ||
| 4 | 16 | 5 | 2022-10-01 | Clemson | North Carolina State | REG (Conf) | W 30-20 | ||
| 5 | 17 | 7 | 2022-10-15 | Clemson | @ | Florida State | REG (Conf) | W 34-28 | |
| 6 | 18 | 8 | 2022-10-22 | Clemson | Syracuse | REG (Conf) | W 27-21 | ||
| 7 | 19 | 10 | 2022-11-12 | Clemson | Louisville | REG (Conf) | W 31-16 | ||
| 8 | 20 | 11 | 2022-11-19 | Clemson | Miami (FL) | REG (Conf) | W 40-10 | ||
| 9 | 21 | 12 | 2022-11-26 | Clemson | South Carolina | REG (Non-Conf) | L 30-31 | ||
| 10 | 22 | 13 | 2022-12-03 | Clemson | N | North Carolina | Conf Championship | W 39-10 | |
| 11 | 23 | 14 | 2022-12-30 | Clemson | N | Tennessee | Bowl | L 14-31 | Orange Bowl |
| 9-2 |
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