| Rk | Date | School | Opponent | ||
|---|---|---|---|---|---|
| 1 | 2021-09-06 | Louisville | N | Mississippi | L |
| 2 | 2021-09-25 | Louisville | @ | Florida State | W |
| 3 | 2021-10-02 | Louisville | @ | Wake Forest | L |
| 4 | 2021-10-09 | Louisville | Virginia | L | |
| 5 | 2021-10-30 | Louisville | @ | North Carolina State | L |
| 6 | 2021-11-13 | Louisville | Syracuse | W | |
| 7 | 2021-11-27 | Louisville | Kentucky | L | |
| 8 | 2021-12-28 | Louisville | N | Air Force* | L |
| 8 Games | |||||
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