| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 9 | 1 | 2021-09-02 | Ohio State | @ | Minnesota | REG (Conf) | W 45-31 | |
| 2 | 10 | 2 | 2021-09-11 | Ohio State | Oregon | REG (Non-Conf) | L 28-35 | ||
| 3 | 11 | 3 | 2021-09-18 | Ohio State | Tulsa | REG (Non-Conf) | W 41-20 | ||
| 4 | 12 | 6 | 2021-10-09 | Ohio State | Maryland | REG (Conf) | W 66-17 | ||
| 5 | 13 | 7 | 2021-10-23 | Ohio State | @ | Indiana | REG (Conf) | W 54-7 | |
| 6 | 14 | 8 | 2021-10-30 | Ohio State | Penn State | REG (Conf) | W 33-24 | ||
| 7 | 15 | 9 | 2021-11-06 | Ohio State | @ | Nebraska | REG (Conf) | W 26-17 | |
| 8 | 16 | 10 | 2021-11-13 | Ohio State | Purdue | REG (Conf) | W 59-31 | ||
| 9 | 17 | 11 | 2021-11-20 | Ohio State | Michigan State | REG (Conf) | W 56-7 | ||
| 10 | 18 | 12 | 2021-11-27 | Ohio State | @ | Michigan | REG (Conf) | L 27-42 | |
| 11 | 19 | 13 | 2022-01-01 | Ohio State | N | Utah | Bowl | W 48-45 | Rose Bowl |
| 9-2 |
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