| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 40 | 1 | 2021-09-04 | Clemson | N | Georgia | REG (Non-Conf) | L 3-10 |
| 2 | 41 | 2 | 2021-09-11 | Clemson | South Carolina St. | REG (Non-Conf) | W 49-3 | |
| 3 | 42 | 3 | 2021-09-18 | Clemson | Georgia Tech | REG (Conf) | W 14-8 | |
| 4 | 43 | 4 | 2021-09-25 | Clemson | @ | North Carolina State | REG (Conf) | L 21-27 |
| 5 | 44 | 5 | 2021-10-02 | Clemson | Boston College | REG (Conf) | W 19-13 | |
| 6 | 45 | 6 | 2021-10-15 | Clemson | @ | Syracuse | REG (Conf) | W 17-14 |
| 7 | 46 | 7 | 2021-10-23 | Clemson | @ | Pitt | REG (Conf) | L 17-27 |
| 4-3 |
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