| Rk | Date | School | Opponent | ||
|---|---|---|---|---|---|
| 1 | 2021-09-04 | Iowa | Indiana | W | |
| 2 | 2021-09-11 | Iowa | @ | Iowa State | W |
| 3 | 2021-09-18 | Iowa | Kent State | W | |
| 4 | 2021-09-25 | Iowa | Colorado State | W | |
| 5 | 2021-10-01 | Iowa | @ | Maryland | W |
| 6 | 2021-10-09 | Iowa | Penn State | W | |
| 7 | 2021-10-16 | Iowa | Purdue | L | |
| 8 | 2021-10-30 | Iowa | @ | Wisconsin | L |
| 9 | 2021-11-06 | Iowa | @ | Northwestern | W |
| 10 | 2021-11-26 | Iowa | @ | Nebraska | W |
| 11 | 2021-12-04 | Iowa | N | Michigan | L |
| 12 | 2022-01-01 | Iowa | N | Kentucky* | L |
| 12 Games | |||||
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