| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 14 | 1 | 2022-09-05 | Clemson | @ | Georgia Tech | REG (Conf) | W 41-10 |
| 2 | 15 | 2 | 2022-09-10 | Clemson | Furman | REG (Non-Conf) | W 35-12 | |
| 3 | 16 | 3 | 2022-09-17 | Clemson | Louisiana Tech | REG (Non-Conf) | W 48-20 | |
| 4 | 17 | 4 | 2022-09-24 | Clemson | @ | Wake Forest | REG (Conf) | W 51-45 (2OT) |
| 5 | 18 | 5 | 2022-10-01 | Clemson | North Carolina State | REG (Conf) | W 30-20 | |
| 6 | 19 | 6 | 2022-10-08 | Clemson | @ | Boston College | REG (Conf) | W 31-3 |
| 7 | 20 | 7 | 2022-10-15 | Clemson | @ | Florida State | REG (Conf) | W 34-28 |
| 8 | 21 | 8 | 2022-10-22 | Clemson | Syracuse | REG (Conf) | W 27-21 | |
| 9 | 22 | 9 | 2022-11-05 | Clemson | @ | Notre Dame | REG (Non-Conf) | L 14-35 |
| 10 | 23 | 10 | 2022-11-12 | Clemson | Louisville | REG (Conf) | W 31-16 | |
| 11 | 24 | 11 | 2022-11-19 | Clemson | Miami (FL) | REG (Conf) | W 40-10 | |
| 10-1 |
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