| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 1 | 2021-09-04 | Clemson | N | Georgia | REG (Non-Conf) | L 3-10 | |
| 2 | 2 | 2 | 2021-09-11 | Clemson | South Carolina St. | REG (Non-Conf) | W 49-3 | ||
| 3 | 3 | 3 | 2021-09-18 | Clemson | Georgia Tech | REG (Conf) | W 14-8 | ||
| 4 | 4 | 4 | 2021-09-25 | Clemson | @ | North Carolina State | REG (Conf) | L 21-27 | |
| 5 | 5 | 5 | 2021-10-02 | Clemson | Boston College | REG (Conf) | W 19-13 | ||
| 6 | 6 | 6 | 2021-10-15 | Clemson | @ | Syracuse | REG (Conf) | W 17-14 | |
| 7 | 7 | 7 | 2021-10-23 | Clemson | @ | Pitt | REG (Conf) | L 17-27 | |
| 8 | 8 | 8 | 2021-10-30 | Clemson | Florida State | REG (Conf) | W 30-20 | ||
| 9 | 9 | 9 | 2021-11-06 | Clemson | @ | Louisville | REG (Conf) | W 30-24 | |
| 10 | 10 | 10 | 2021-11-13 | Clemson | Connecticut | REG (Non-Conf) | W 44-7 | ||
| 11 | 11 | 11 | 2021-11-20 | Clemson | Wake Forest | REG (Conf) | W 48-27 | ||
| 12 | 12 | 12 | 2021-11-27 | Clemson | @ | South Carolina | REG (Non-Conf) | W 30-0 | |
| 13 | 13 | 13 | 2021-12-29 | Clemson | N | Iowa State | Bowl | W 20-13 | Cheez-It Bowl |
| 10-3 |
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