| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 5 | 1 | 2022-09-01 | Purdue | Penn State | REG (Conf) | L 31-35 | |
| 2 | 6 | 2 | 2022-09-10 | Purdue | Indiana St. | REG (Non-Conf) | W 56-0 | |
| 3 | 7 | 3 | 2022-09-17 | Purdue | @ | Syracuse | REG (Non-Conf) | L 29-32 |
| 4 | 8 | 4 | 2022-09-24 | Purdue | Florida Atlantic | REG (Non-Conf) | W 28-26 | |
| 5 | 9 | 5 | 2022-10-01 | Purdue | @ | Minnesota | REG (Conf) | W 20-10 |
| 6 | 10 | 6 | 2022-10-08 | Purdue | @ | Maryland | REG (Conf) | W 31-29 |
| 7 | 11 | 7 | 2022-10-15 | Purdue | Nebraska | REG (Conf) | W 43-37 | |
| 8 | 12 | 8 | 2022-10-22 | Purdue | @ | Wisconsin | REG (Conf) | L 24-35 |
| 9 | 13 | 9 | 2022-11-05 | Purdue | Iowa | REG (Conf) | L 3-24 | |
| 10 | 14 | 10 | 2022-11-12 | Purdue | @ | Illinois | REG (Conf) | W 31-24 |
| 11 | 15 | 11 | 2022-11-19 | Purdue | Northwestern | REG (Conf) | W 17-9 | |
| 12 | 16 | 12 | 2022-11-26 | Purdue | @ | Indiana | REG (Conf) | W 30-16 |
| 13 | 17 | 13 | 2022-12-03 | Purdue | N | Michigan | Conf Championship | L 22-43 |
| 8-5 |
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