| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 10 | 1 | 2016-09-01 | Louisville | Charlotte | REG (Non-Conf) | W 70-14 | |
| 2 | 11 | 2 | 2016-09-09 | Louisville | @ | Syracuse | REG (Conf) | W 62-28 |
| 3 | 12 | 3 | 2016-09-17 | Louisville | Florida State | REG (Conf) | W 63-20 | |
| 4 | 13 | 4 | 2016-09-24 | Louisville | @ | Marshall | REG (Non-Conf) | W 59-28 |
| 5 | 14 | 5 | 2016-10-01 | Louisville | @ | Clemson | REG (Conf) | L 36-42 |
| 6 | 15 | 6 | 2016-10-14 | Louisville | Duke | REG (Conf) | W 24-14 | |
| 7 | 16 | 7 | 2016-10-22 | Louisville | North Carolina State | REG (Conf) | W 54-13 | |
| 8 | 17 | 9 | 2016-11-05 | Louisville | @ | Boston College | REG (Conf) | W 52-7 |
| 9 | 18 | 10 | 2016-11-12 | Louisville | Wake Forest | REG (Conf) | W 44-12 | |
| 10 | 19 | 12 | 2016-11-26 | Louisville | Kentucky | REG (Non-Conf) | L 38-41 | |
| 8-2 |
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