Output includes regular season games from 2000 to 2024 and bowl games from 2002 to 2024.
| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 1 | 2 | 2017-09-16 | Houston | Rice | REG (Non-Conf) | W 38-3 | ||
| 2 | 2 | 9 | 2017-11-04 | Houston | East Carolina | REG (Conf) | W 52-27 | ||
| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
| 3 | 3 | 1 | 2018-09-01 | Houston | @ | Rice | REG (Non-Conf) | W 45-27 | |
| 4 | 4 | 2 | 2018-09-08 | Houston | Arizona | REG (Non-Conf) | W 45-18 | ||
| 5 | 5 | 3 | 2018-09-15 | Houston | @ | Texas Tech | REG (Non-Conf) | L 49-63 | |
| 6 | 6 | 4 | 2018-09-22 | Houston | Texas Southern | REG (Non-Conf) | W 70-14 | ||
| 7 | 7 | 5 | 2018-10-04 | Houston | Tulsa | REG (Conf) | W 41-26 | ||
| 8 | 8 | 6 | 2018-10-13 | Houston | @ | East Carolina | REG (Conf) | W 42-20 | |
| 9 | 9 | 7 | 2018-10-20 | Houston | @ | Navy | REG (Conf) | W 49-36 | |
| 10 | 10 | 8 | 2018-10-27 | Houston | South Florida | REG (Conf) | W 57-36 | ||
| 11 | 11 | 9 | 2018-11-03 | Houston | @ | SMU | REG (Conf) | L 31-45 | |
| 12 | 12 | 10 | 2018-11-10 | Houston | Temple | REG (Conf) | L 49-59 | ||
| 13 | 13 | 11 | 2018-11-15 | Houston | Tulane | REG (Conf) | W 48-17 | ||
| 14 | 14 | 12 | 2018-11-23 | Houston | @ | Memphis | REG (Conf) | L 31-52 | |
| 15 | 15 | 13 | 2018-12-22 | Houston | N | Army | Bowl | L 14-70 | Armed Forces Bowl |
| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
| 16 | 16 | 1 | 2019-09-01 | Houston | @ | Oklahoma | REG (Non-Conf) | L 31-49 | |
| 17 | 17 | 2 | 2019-09-07 | Houston | Prairie View | REG (Non-Conf) | W 37-17 | ||
| 18 | 18 | 3 | 2019-09-13 | Houston | N | Washington State | REG (Non-Conf) | L 24-31 | |
| 19 | 19 | 4 | 2019-09-19 | Houston | @ | Tulane | REG (Conf) | L 31-38 | |
| 20 | 20 | 5 | 2019-09-28 | Houston | @ | North Texas | REG (Non-Conf) | W 46-25 | |
| 21 | 21 | 6 | 2019-10-12 | Houston | Cincinnati | REG (Conf) | L 23-38 | ||
| 22 | 22 | 7 | 2019-10-19 | Houston | @ | Connecticut | REG (Conf) | W 24-17 | |
| 23 | 23 | 8 | 2019-10-24 | Houston | SMU | REG (Conf) | L 31-34 | ||
| 24 | 24 | 9 | 2019-11-02 | Houston | @ | UCF | REG (Conf) | L 29-44 | |
| 25 | 25 | 10 | 2019-11-16 | Houston | Memphis | REG (Conf) | L 27-45 | ||
| 26 | 26 | 11 | 2019-11-23 | Houston | @ | Tulsa | REG (Conf) | W 24-14 | |
| 27 | 27 | 12 | 2019-11-30 | Houston | Navy | REG (Conf) | L 41-56 | ||
| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
| 28 | 28 | 1 | 2020-10-08 | Houston | Tulane | REG (Conf) | W 49-31 | ||
| 29 | 29 | 2 | 2020-10-16 | Houston | BYU | REG (Non-Conf) | L 26-43 | ||
| 30 | 30 | 3 | 2020-10-24 | Houston | @ | Navy | REG (Conf) | W 37-21 | |
| 31 | 31 | 4 | 2020-10-31 | Houston | UCF | REG (Conf) | L 21-44 | ||
| 32 | 32 | 5 | 2020-11-07 | Houston | @ | Cincinnati | REG (Conf) | L 10-38 | |
| 33 | 33 | 6 | 2020-11-14 | Houston | South Florida | REG (Conf) | W 56-21 | ||
| 34 | 34 | 7 | 2020-12-12 | Houston | @ | Memphis | REG (Conf) | L 27-30 | |
| 35 | 35 | 8 | 2020-12-24 | Houston | N | Hawaii | Bowl | L 14-28 | New Mexico Bowl |
| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
| 36 | 36 | 1 | 2021-09-04 | Houston | N | Texas Tech | REG (Non-Conf) | L 21-38 | |
| 37 | 37 | 2 | 2021-09-11 | Houston | @ | Rice | REG (Non-Conf) | W 44-7 | |
| 38 | 38 | 3 | 2021-09-18 | Houston | Grambling | REG (Non-Conf) | W 45-0 | ||
| 39 | 39 | 4 | 2021-09-25 | Houston | Navy | REG (Conf) | W 28-20 | ||
| 40 | 40 | 5 | 2021-10-01 | Houston | @ | Tulsa | REG (Conf) | W 45-10 | |
| 41 | 41 | 6 | 2021-10-07 | Houston | @ | Tulane | REG (Conf) | W 40-22 | |
| 42 | 42 | 7 | 2021-10-23 | Houston | East Carolina | REG (Conf) | W 31-24 | ||
| 43 | 43 | 8 | 2021-10-30 | Houston | SMU | REG (Conf) | W 44-37 | ||
| 44 | 44 | 9 | 2021-11-06 | Houston | @ | South Florida | REG (Conf) | W 54-42 | |
| 45 | 45 | 10 | 2021-11-13 | Houston | @ | Temple | REG (Conf) | W 37-8 | |
| 46 | 46 | 11 | 2021-11-19 | Houston | Memphis | REG (Conf) | W 31-13 | ||
| 47 | 47 | 12 | 2021-11-27 | Houston | @ | Connecticut | REG (Non-Conf) | W 45-17 | |
| 48 | 48 | 13 | 2021-12-04 | Houston | @ | Cincinnati | Conf Championship | L 20-35 | |
| 49 | 49 | 14 | 2021-12-28 | Houston | N | Auburn | Bowl | W 17-13 | Birmingham Bowl |
| 29-20 |
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