| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 9 | 1 | 2021-09-04 | Mississippi State | Louisiana Tech | REG (Non-Conf) | W 35-34 | ||
| 2 | 10 | 2 | 2021-09-11 | Mississippi State | North Carolina State | REG (Non-Conf) | W 24-10 | ||
| 3 | 11 | 3 | 2021-09-18 | Mississippi State | @ | Memphis | REG (Non-Conf) | L 29-31 | |
| 4 | 12 | 4 | 2021-09-25 | Mississippi State | LSU | REG (Conf) | L 25-28 | ||
| 5 | 13 | 5 | 2021-10-02 | Mississippi State | @ | Texas A&M | REG (Conf) | W 26-22 | |
| 6 | 14 | 6 | 2021-10-16 | Mississippi State | Alabama | REG (Conf) | L 9-49 | ||
| 7 | 15 | 7 | 2021-10-23 | Mississippi State | @ | Vanderbilt | REG (Conf) | W 45-6 | |
| 8 | 16 | 8 | 2021-10-30 | Mississippi State | Kentucky | REG (Conf) | W 31-17 | ||
| 9 | 17 | 9 | 2021-11-06 | Mississippi State | @ | Arkansas | REG (Conf) | L 28-31 | |
| 10 | 18 | 10 | 2021-11-13 | Mississippi State | @ | Auburn | REG (Conf) | W 43-34 | |
| 11 | 19 | 11 | 2021-11-20 | Mississippi State | Tennessee St. | REG (Non-Conf) | W 55-10 | ||
| 12 | 20 | 12 | 2021-11-25 | Mississippi State | Ole Miss | REG (Conf) | L 21-31 | ||
| 13 | 21 | 13 | 2021-12-28 | Mississippi State | N | Texas Tech | Bowl | L 7-34 | Liberty Bowl |
| 7-6 |
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