| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | |
|---|---|---|---|---|---|---|---|---|
| 1 | 6 | 1 | 2021-09-04 | Rice | @ | Arkansas | REG (Non-Conf) | L 17-38 |
| 2 | 7 | 2 | 2021-09-11 | Rice | Houston | REG (Non-Conf) | L 7-44 | |
| 3 | 8 | 3 | 2021-09-18 | Rice | @ | Texas | REG (Non-Conf) | L 0-58 |
| 4 | 9 | 4 | 2021-09-25 | Rice | Texas Southern | REG (Non-Conf) | W 48-34 | |
| 5 | 10 | 5 | 2021-10-02 | Rice | Southern Mississippi | REG (Conf) | W 24-19 | |
| 6 | 11 | 6 | 2021-10-16 | Rice | @ | UTSA | REG (Conf) | L 0-45 |
| 7 | 12 | 7 | 2021-10-23 | Rice | @ | UAB | REG (Conf) | W 30-24 |
| 8 | 13 | 9 | 2021-11-06 | Rice | @ | Charlotte | REG (Conf) | L 24-31 |
| 9 | 14 | 10 | 2021-11-13 | Rice | Western Kentucky | REG (Conf) | L 21-42 | |
| 10 | 15 | 11 | 2021-11-20 | Rice | @ | UTEP | REG (Conf) | L 28-38 |
| 11 | 16 | 12 | 2021-11-27 | Rice | Louisiana Tech | REG (Conf) | W 35-31 | |
| 4-7 |
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