| Rk | Gcar | Gtm | Date | School | Opponent | Type | Result | Bowl | |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 39 | 1 | 2021-09-04 | Oklahoma State | Missouri St. | REG (Non-Conf) | W 23-16 | ||
| 2 | 40 | 2 | 2021-09-11 | Oklahoma State | Tulsa | REG (Non-Conf) | W 28-23 | ||
| 3 | 41 | 3 | 2021-09-18 | Oklahoma State | @ | Boise State | REG (Non-Conf) | W 21-20 | |
| 4 | 42 | 4 | 2021-09-25 | Oklahoma State | Kansas State | REG (Conf) | W 31-20 | ||
| 5 | 43 | 5 | 2021-10-02 | Oklahoma State | Baylor | REG (Conf) | W 24-14 | ||
| 6 | 44 | 6 | 2021-10-16 | Oklahoma State | @ | Texas | REG (Conf) | W 32-24 | |
| 7 | 45 | 7 | 2021-10-23 | Oklahoma State | @ | Iowa State | REG (Conf) | L 21-24 | |
| 8 | 46 | 8 | 2021-10-30 | Oklahoma State | Kansas | REG (Conf) | W 55-3 | ||
| 9 | 47 | 9 | 2021-11-06 | Oklahoma State | @ | West Virginia | REG (Conf) | W 24-3 | |
| 10 | 48 | 11 | 2021-11-20 | Oklahoma State | @ | Texas Tech | REG (Conf) | W 23-0 | |
| 11 | 49 | 12 | 2021-11-27 | Oklahoma State | Oklahoma | REG (Conf) | W 37-33 | ||
| 12 | 50 | 13 | 2021-12-04 | Oklahoma State | N | Baylor | Conf Championship | L 16-21 | |
| 13 | 51 | 14 | 2022-01-01 | Oklahoma State | N | Notre Dame | Bowl | W 37-35 | Fiesta Bowl |
| 11-2 |
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